A. How does it work?
1. Androgen transport mechanism
Genes typically strongly impact sex hormone production in men and regulate its levels as the body matures as well as during adulthood. Similarly, the way cells will respond to sex hormones is also predetermined by a person’s genetic makeup. Indeed, a study has shown that the passive diffusion of the androgen hormone in the blood and its effective associations with receptors relies on a protein called the sex hormone-binding globulin (SHBG). Heredity accounts for up to 50% of the SHBG’s strength, while numerous genes – PRMT6, GCKR, ZBTB10, JMJD1C, SLCO1B1, NR2F2, ZNF652, TDGF3, LHCGR, BAIAP2L1 and UGT2B15- play a role in regulating SHBG production.
2. Metabolic pathway
In the male organism, the health of the gut microbiota impacts the metabolism as well as hormonal production.
3. Good nutrition
A balanced diet is particularly important to the male adult body given that nutrients regulate the endocrines; combined with the adrenal glands and testicles, these play an essential role in androgen production.
ROS (Reactive Oxygen Species) and RNS (Reactive Nitrogen Species) free radicals constitute a significant threat to cells present in the human body. Generated at the final stages of the metabolic process, their accumulation results in oxidative stress, which can harm protein, lipids, as well as DNA present in body cells, which ultimately can lead to their deterioration and a disturbance in the normal functioning of the organism. Such a development can bring about acute conditions caused by dysfunctions in both hormonal and reproductive systems.
4. Androgen and reproductive disorders
Long-term chronic inflammation is also responsible for dysfunctions in the endocrine gland, which can negatively impact androgen levels.
C. Towards developing effective solutions
1. Further research
Several medical studies evidence the fact that a range of fatal illnesses are caused by the overlap between recessive genes and the androgen function. Currently, however, further research needs to be conducted to develop potential treatment options in compliance with medical practice.
2. Providing prebiotics and probiotics
Prebiotics and non-digestible polysaccharides can harmonize and even out gut bacteria to optimize and prevent imbalances in the gut microbiota. Prebiotics should not be confused with probiotics, live bacteria of which the properties are beneficial to the digestive and metabolic systems, as well as the gut flora. Hence, a balanced gut bacterium is essential to adult men’s health.
3. Nourishing foods
Nutrition is especially important to hormonal production in adults. Nutrients that are vital to sex hormone production are: