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A. How does it work?

(Why What)


1. Testosterone hormones

Genes typically strongly impact sex hormone production in men and regulate its levels as the body matures as well as during adulthood. Similarly, the way cells will respond to sex hormones is also predetermined by a person’s genetic makeup. Indeed, a study has shown that the passive diffusion of the androgen hormone in the blood and its effective associations with receptors relies on a protein called the sex hormone-binding globulin (SHBG). Heredity accounts for up to 50% of the SHBG’s strength, while numerous genes – PRMT6, GCKR, ZBTB10, JMJD1C, SLCO1B1, NR2F2, ZNF652, TDGF3, LHCGR, BAIAP2L1 and UGT2B15- play a role in regulating SHBG production.

2. Metabolic pathway

In the male organism, the health of the gut microbiota impacts the metabolism as well as hormonal production. Indeed, research has shown that an imbalance typically generates bacterial endotoxin
(i.e., lipopolysaccharide (LPS)), a toxin which contaminates first the intestines, then the blood, to only then spread to the rest of the body. The damage leads to a chronic inflammation of the body, which over time can provoke a testosterone deficiency (TD).

3. Good nutrition

A balanced diet is particularly important to the male adult body given that nutrients regulate the endocrines; combined with the adrenal glands and testicles, these play an essential role in androgen production. Furthermore, as the body ages, it becomes more vulnerable to a range of threats and conditions, which buttresses the significance of adequate diet among the elderly.

4. Antioxidants

ROS (Reactive Oxygen Species) and RNS (Reactive Nitrogen Species) free radicals constitute a significant threat to cells present in the human body. Generated at the final stages of the metabolic process, their accumulation results in oxidative stress, which can harm protein, lipids, as well as DNA present in body cells, which ultimately can lead to their deterioration and a disturbance in the normal functioning of the organism. Such a development can bring about acute conditions caused by dysfunctions in both hormonal and reproductive systems, such as estrogen imbalance, reproductive failure as well as sexual impotence.

B. In the absence of the elements

listed in A,

the following may occur:

1. Genetic Influence

Adults with genetic disorders may suffer a range of conditions which are particularly noticeable as the body ages. These are:

1.1 Erectile dysfunction and testicular atrophy (a major source of concern among senior men)

1.2 A dwindling of the metabolic system, and an accumulation of fat on the belly and the chest.

1.3 Low bone mass and osteoporosis

1.4 Sarcopenia (muscle loss caused by aging)

1.5 Recurrent hot flashes

1.6 Hair loss and baldness

1.7 Insomnia

1.8 Mood swings and stress (which varies in function of a person’s lifestyle)

1.9 Depleted motivation

1.10 Loss of focus and a decrease in attention span, memory loss

2. Dysbiosis

The gravity of bacterial imbalances is such that these alone can upset the entire organism, including the brain and the endocrinal system, which is typically triggered by its chronic inflammation. Furthermore, a disruption of the endocrines has been linked with dysfunctions linked to the male sex hormone, androgen, which makes seniors vulnerable to a range of severe conditions.

3. Endocrine system disorder

Regardless of a person’s age, an unhealthy diet always negatively impacts the organism. The well-functioning of senior’s bodies is reliant on vital nutrients and vitamins for the optimization and production of sex hormones. Malnutrition, often characteristic in seniors, can lead to an androgen deficiency.

4. Androgen and reproductive disorders

Long-term chronic inflammation is also responsible for dysfunctions in the endocrine gland, which can negatively impact androgen levels, especially among seniors.

C. Towards developing effective solutions

1. Further research

Several medical studies evidence the fact that a range of fatal illnesses are caused by the overlap between recessive genes and the androgen function. Currently, however, further research needs to be conducted to develop potential treatment options in compliance with medical practice.

2. Providing prebiotics and probiotics

Prebiotics and non-digestible polysaccharides can harmonize and even out gut bacteria to optimize and prevent imbalances in the gut microbiota. Prebiotics should not be confused with probiotics, live bacteria of which the properties are beneficial to the digestive and metabolic systems, as well as the gut flora.

3. Nourishing foods

Nutrition is especially important to hormonal production in adults. Nutrients that are vital to sex hormone production are:

Essential nutritions for balancing androgen level


3.1 Calciferol

Calciferol, commonly found in marine fish, eggs, and milk, works like body hormone. It’s advised that protein deficiency may lead to lower sex hormone, whereas calcium boron improves the level of the male sex hormone.

3.2 Zinc

Meat, eggs, and soybeans, cereals, and oyster are rich in zinc, an important chemical element for hundreds of body system. Moreover, it’s widely known as a male sex hormone booster.

3.3 Phenol

Apart from encouraging the antioxidant system, phenol promotes a male sex hormone named testosterone resulting in physical masculine traits. Phenol also improves male fertility by increasing both the quantity and the quality of sperms.

4. Providing active substances that prevent free radicals

The antioxidant defense, which serves the critical function of shielding the body against harmful free radicals, can be enhanced by means of the adoption of a nutritive diet, rich in antioxidants. Indeed, antioxidants prevent premature cellular aging and irregular hormonal activity.


There are in total two different types of antioxidants :

1. Enzymatic antioxidants

Enzymatic antioxidants, on the one hand, transform themselves into enzymes such as superoxide dismutases (SODs), catalase, and others that form the glutathione system.

2. Non Enzymatic antioxidants

Non-enzymatic antioxidants consist of the following: ascorbic acid (i.e., vitamin C), glutathione, melatonin, tocopherols and tocotrienols (i.e., Vitamin E), as well as carotenoids, flavonoids and uric acid.

Consuming foods on a regular basis that are rich in antioxidants will facilitate the elimination of excessive of free radicals that typically harm the DNA and cell structures.

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