A. How does it work?
1. Testosterone hormones
Genes typically strongly impact sex hormone production in men and regulate its levels as the body matures as well as during adulthood. Similarly, the way cells will respond to sex hormones is also predetermined by a person’s genetic makeup. Indeed, a study has shown that the passive diffusion of the androgen hormone in the blood and its effective associations with receptors relies on a protein called the sex hormone-binding globulin (SHBG). Heredity accounts for up to 50% of the SHBG’s strength, while numerous genes – PRMT6, GCKR, ZBTB10, JMJD1C, SLCO1B1, NR2F2, ZNF652, TDGF3, LHCGR, BAIAP2L1 and UGT2B15- play a role in regulating SHBG production.
2. Metabolic pathway
In the male organism, the health of the gut microbiota impacts the metabolism as well as hormonal production. Indeed, research has shown that an imbalance typically generates bacterial endotoxin
(i.e., lipopolysaccharide (LPS)), a toxin which contaminates first the intestines, then the blood, to only then spread to the rest of the body. The damage leads to a chronic inflammation of the body, which over time can provoke a testosterone deficiency (TD).
3. Good nutrition
A balanced diet is particularly important to the male adult body given that nutrients regulate the endocrines; combined with the adrenal glands and testicles, these play an essential role in androgen production. Furthermore, as the body ages, it becomes more vulnerable to a range of threats and conditions, which buttresses the significance of adequate diet among the elderly.
ROS (Reactive Oxygen Species) and RNS (Reactive Nitrogen Species) free radicals constitute a significant threat to cells present in the human body. Generated at the final stages of the metabolic process, their accumulation results in oxidative stress, which can harm protein, lipids, as well as DNA present in body cells, which ultimately can lead to their deterioration and a disturbance in the normal functioning of the organism. Such a development can bring about acute conditions caused by dysfunctions in both hormonal and reproductive systems, such as estrogen imbalance, reproductive failure as well as sexual impotence.
B. In the absence of the elements
listed in A,
the following may occur:
4. Androgen and reproductive disorders
Long-term chronic inflammation is also responsible for dysfunctions in the endocrine gland, which can negatively impact androgen levels, especially among seniors.
C. Towards developing effective solutions
Apart from encouraging the antioxidant system, phenol promotes a male sex hormone named testosterone resulting in physical masculine traits. Phenol also improves male fertility by increasing both the quantity and the quality of sperms.